Poster Presentation 9th GeneMappers Conference 2012

Genome-Wide Association Study of Attention-Deficit Hyperactivity Disorder (ADHD) in Adults Using a Trait Measure of Symptoms (#108)

Jane Ebejer 1 , Sarah Medland , Margie Wright , David Duffy
  1. Queensland Instutite of Medical Research, HERSTON, QLD, Australia

Previous association studies of ADHD have measured symptoms on a scale of severity, truncating the population variance for behavioural responses at the opposite end of the ADHD scale. ADHD data were collected from 1863 adults, from 736 families using the Strengths and Weaknesses of Normal Behaviour (SWAN) scale which taps the continuum from normal to clinical behaviours. As expected the heritability of the inattentive, hyperactive-impulsive subtypes was high, (.62 and .81 respectively). We conducted genome-wide association analyses with genotypic data imputed to HapMap 2. No variants reached genome-wide significance, there were suggestive associations (p-values ~ 10-7). To follow up these results we conducted gene-based tests using VEGAS. Results will be discussed.